|
KMID : 0604520140400010095
|
|
Journal of the Society of Cosmetic Scientists of Korea
2014 Volume.40 No. 1 p.95 ~ p.108
|
|
|
Screening for Anti-inflammatory Activities in Extracts from Korean Herb Medicines
|
|
An Sang-Mi
Kim Hyoung-Gun
Choi Eun-Jung
Hwang Hyoung-Hoon
Lee Eun-Seok
Baek Ji-Hwoon
Boo Yong-Chool
Koh Jae-Sook
|
|
|
Abstract
|
|
|
|
Cosmetics are products used over long periods by the public, and their safety is very important. Contact dermatitisinduced by cosmetics is the result of an inflammatory response of the skin to direct irritancy. The initial eventthat this inflammatory response is observed is the release of pro-inflammatory cytokines. In this study, the anti-inflammatoryactivities of extracts from Korean herb medicines were investigated using RAW264.7 macrophage. Amongthe fifty one extracts tested, the ethanol extracts from Biotae Orientalis Folium, Biotae Orientalis Folium (roasted),Cyperi Rhizoma, Nepetae Spica, Benincasae Semen, Dioscoreae Rhizoma, Dioscoreae Rhizoma (roasted), Mori Ramulus,Pini Ramulus and Alismatis Rhizoma reduced the cytotoxicity and inhibited the productions of Nitric oxide (NO) andcytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-αn lipopolysaccharide (LPS)-inducedRAW264.7 macrophage. Additionally, they didn’t induce the skin irritation when tested the human patch test. Overall,the result of this study suggests that the extracts of the ten Korean herb medicines are useful cosmetic agents for preventingthe skin irritation.
|
|
|
KEYWORD
|
|
|
Korean herb medicines, anti-inflammatory activities, Skin irritation, Cosmetics
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|